Polymorphisms for Interleukin 1β Exon 5 and Interleukin 1 Receptor Antagonist in Taiwanese Children With Febrile Convulsions
نویسندگان
چکیده
منابع مشابه
Interleukin-1β and interleukin-1receptor antagonist polymorphisms in Egyptian children with febrile seizures
Febrile seizure is the most common seizure disorder of childhood. Of the pro-inflammatory cytokines, interleukin-1 is defined as the first endogenous pyrogen.We designed this study to investigate single-nucleotide polymorphisms (SNPs) situated at positions -31 (C/T), and -511 (C/T) of interleukin-1beta (IL-1β) gene promoter and interleukin-1receptor antagonist (IL-1RA) gene variable number of t...
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UNLABELLED Very little is known about the role of interleukin-1β (IL-1β) and interleukin-18 (IL-18) in urticaria. MATERIAL AND METHODS Serum levels of IL-1β, IL-1 receptor antagonist (IL-1RA), and IL-18 were measured in 56 children with urticaria and in 41 healthy subjects. RESULTS Serum IL-1β did not differ between children with acute urticaria and controls. Children with single episode of...
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OBJECTIVES β-cell dysfunction and apoptosis associated with islet inflammation play a key role in the pathogenesis of type 2 diabetes (T2D). Growing evidence suggests that islet amyloid, formed by aggregation of human islet amyloid polypeptide (hIAPP), contributes to islet inflammation and β-cell death in T2D. We recently showed the role of interleukin-1β (IL-1β)/Fas/caspase-8 apoptotic pathway...
متن کاملInterleukin-1 receptor antagonist.
IL-1ra is the first described naturally occurring receptor antagonist of any cytokine or hormone-like molecule. IL-1ra is a member of the IL-1 family by three criteria: amino acid sequence homology of 26 to 30% to IL-1 beta and 19% to IL-1 alpha; similarities in gene structure; and common gene localization to human chromosome 2q14. Two structural variants of IL-1ra exist: sIL-1ra, a secretory m...
متن کاملInterleukin-1 receptor antagonist gene polymorphisms in carotid atherosclerosis.
BACKGROUND AND PURPOSE Inflammation plays an important role in the development of atherosclerosis. The gene for the counterinflammatory cytokine interleukin-1 receptor antagonist (IL-1ra) is polymorphic, and high frequencies of allele 2 have been found to be associated with other inflammatory diseases. This study examined the association of allele and carrier frequencies of the IL-1ra gene with...
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ژورنال
عنوان ژورنال: Archives of Pediatrics & Adolescent Medicine
سال: 2002
ISSN: 1072-4710
DOI: 10.1001/archpedi.156.6.545